RAF Typhoon jets have operated alongside France's air force in a coordinated attack targeting an underground arms cache in Syria used by the IS group, per a report from the UK's MoD.
The facility, identified by reconnaissance, was believed to be storing arms and explosives, the statement said, and was situated in mountains just above Palmyra in central Syria.
"The RAF jets employed laser-guided Paveway IV weapons to hit a series of approach shafts providing entry to the facility... initial indications suggest the objective was successfully hit," the ministry announced.
There was no indication of any civilian casualties in the operation on Saturday evening and each participating jet returned safely, the ministry further stated.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as the so-called Islamic State - enforced militant control over significant areas in Syria and Iraq until 2019.
"This operation underscores our UK leadership, and resolve to work closely with our partners, to eliminate any re-emergence of IS and their harmful and extremist ideologies in the region," the British Defence Secretary the minister stated.
UK warplanes have performed surveillance missions over Syria to "deter any attempted resurgence" of the group subsequent to its military defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I want to thank all the members of the UK armed forces involved in this strike for their skill and their courage," the Defence Secretary added. "They were part of numerous UK service members deployed over the festive period. This operation, to eliminate militants who endanger our way of life, highlights how UK forces are always on standby, continuously, ensuring Britain's security at home and strong abroad."
In December, the American forces conducted what it termed a "major assault" against IS targets in the country, subsequent to an attack resulted in the deaths of two US servicemembers and a local interpreter in Palmyra.
The United Nations estimates IS still boasts roughly 5-7 thousand fighters in Syria and Iraq.